Prevalence of Survivor Bias in Observational Studies on Fresh Frozen Plasma

Prevalence of survivor bias in observational studies on fresh frozen plasma:erythrocyte ratios in trauma requiring massive transfusion.

Observational studies on transfusion in trauma comparing high versus low plasma:erythrocyte ratio were prone to survivor bias because plasma administration typically started later than erythrocytes. Therefore, early deaths were categorized in the low plasma:erythrocyte group, whereas early survivors had a higher chance of receiving a higher ratio. When early deaths were excluded, however, a bia...

Fresh frozen plasma induced thrombocytopenia

Transfusions of blood products are common in medical practice and can be lifesaving in certain situations. Potentially life threatening reactions could occur and physicians should be alerted. Here we describe a case of thrombocytopenia that was induced by transfusion of fresh frozen plasma (FFP). A 52 years old male presented to the emergency department after two episodes of hematochezia that r...

Reverse survivor bias in observational studies involving cohorts: a lesson from '1:1' trauma studies.

Survivor (immortal time) bias has been extensively covered in the literature.1-5 It occurs in observational studies when there is a time gap between when tallying of mortality begins and when treatment becomes available to some patients.1 By design, all deaths occurring during this time gap are categorised as belonging to the non-treatment group, and only survivors of this initial time gap are ...

Avoiding the misuse of fresh frozen plasma.

APROTININ: EFFECTS ON BLOOD LOSS AND FRESH FROZEN PLASMA REQUIREMENT IN CARDIAC OPERATIONS

 ABSTRACT Background: Aprotinin has been used increasingly to reduce postoperative blood loss in open-heart operations due to the potentialities for complications and high cost, it would seem reasonable to use aprotinin more selectively in small doses in the prime solution of the pump. Methods: We prospectively studied the effect of preoperative low dose aprotinin [2 million units (230mg)] on b...